Stanzaic Forms in Evenki Poetry (the Example of V. Lebedev`s Works) as a Result of Educational Practice

The article studies the characteristics of poetry of the Evens – indigenous peoples of the North, Siberia and the Far East. Relying on Russian literature, the author examines the features of stanzas in the work of poets of the Evens. V. Lebedev`s works are analyzed as poetry examples of a representative of the Evens.В статье исследуются особенности поэзии эвенов – коренных малочисленных народов Севера, Сибири и дальнего Востока. Опираясь на российское литературоведение, автор рассматривает особенности строфики в творчестве эвенских поэтов. В качестве репрезентанта эвенской поэзии анализируется творчество В.д. Лебедева

Bulk-sensitive Photoemission of Mn5Si3

We have carried out a bulk-sensitive high-resolution photoemission experiment on Mn5Si3. The measurements are performed for both core level and valence band states. The Mn core level spectra are deconvoluted into two components corresponding to different crystallographic sites. The asymmetry of each component is of noticeable magnitude. In contrast, the Si 2p spectrum shows a simple Lorentzian shape with low asymmetry. The peaks of the valence band spectrum correspond well to the peak positions predicted by the former band calculation.Comment: To be published in: Solid State Communication

Oriented antibody immobilization to polystyrene macrocarriers for immunoassay modified with hydrazide derivatives of poly(meth)acrylic acid

BACKGROUND: Hydrophobic polystyrene is the most common material for solid phase immunoassay. Proteins are immobilized on polystyrene by passive adsorption, which often causes considerable denaturation. Biological macromolecules were found to better retain their functional activity when immobilized on hydrophilic materials. Polyacrylamide is a common material for solid-phase carriers of biological macromolecules, including immunoreagents used in affinity chromatography. New macroformats for immunoassay modified with activated polyacrylamide derivatives seem to be promising. RESULTS: New polymeric matrices for immunoassay in the form of 0.63-cm balls which contain hydrazide functional groups on hydrophilic polymer spacer arms at their surface shell are synthesized by modification of aldehyde-containing polystyrene balls with hydrazide derivatives of poly(meth)acrylic acid. The beads contain up to 0.31 μmol/cm(2) active hydrazide groups accessible for covalent reaction with periodate-oxidized antibodies. The matrices obtained allow carrying out the oriented antibody immobilization, which increases the functional activity of immunosorbents. CONCLUSIONS: An efficient site-directed antibody immobilization on a macrosupport is realized. The polymer hydrophilic spacer arms are the most convenient and effective tools for oriented antibody coupling with molded materials. The suggested scheme can be used for the modification of any other solid supports containing electrophilic groups reacting with hydrazides

T35 Epigenetic changes in human cervical carcinomas associated with viral induced pathogenesis

Epigenetics investigates mechanisms that control inheritance of gene expression program during somatic cell divisions. These mechanisms include regulation by DNA methylation, histone post-translational modifications and nucleosome positioning, functioning of regulatory non-coding RNAs, control of alternative splicing of mRNA precursors and high-order chromatin organization. Genome-wide loss of epigenetic stability and increased epigenetic plasticity are common features of all tumor types. In normal tissues epigenetic plasticity allow cells to response on environment signals. Thus, in tumor cells its constitutive activation leads to epigenetic heterogeneity that are the additional hallmark of the most of the classical cancers. Cervical cancers are one of the most interesting models for the analysis of the role of epigenetic changes in tumor progression. These types of tumors are associated with infection of human papilloma viruses of so-called high-risk group (HR-HPV) and characterized by well-defined stages of malignant conversion from intraepithelial neoplasias to carcinomas. The viral DNA can persist in episomal form or integrates into the host-cell genome.Cellular genomes encode genetic information in their linear sequence, but appropriate gene expression requires chromosomes to fold into dynamic complex three-dimensional structures. Scaffold/matrix attachment regions (S/MARs) are specialized genomic DNA sequences that take part in organization of these structures. We demonstrated that methylation of S/MARs was required for their attachment to nuclear matrix and that methylation status of S/MARs was changed in cervical cancer cell compared to normal cells.DNA methylation plays an important role in the regulation of gene expression. We found that methylation of the regulatory sequences in the HPV16 genome specifically changes in transformed compared to the normal cervical epithelial cells. Next, we showed that methylation of the transcription factor binding sites modulates the viral oncogene expression. These data suggest that the HPV16 genome methylation may represent an important mechanism that initiates the development of HPV-associated tumors.Using next generation sequencing, we identified pattern of differentially expressed microRNAs in clinical samples of the cervical lesions. We confirmed expression of microRNAs that have been described previously as well as identified new microRNAs that can be potentially involved in the development and progression of cervical cancer. Spectrum of differentially expressed microRNAs includes microRNAs targeting tumor-suppressor genes as well as oncogenes.Telomerase is a key regulator of cell proliferation. This enzyme is silent in normal cells and activated in most of the tumors. Few forms of RNA (hTERT), encoded by telomerase gene were detected in different tumor cells and among them three forms (alfa, beta and gamma) are most well pronounced. We found that in cervical tumors expression of all three forms are significantly increased. In some cases, we also observe higher level of hTERT expression in neighboring “normal tissue”. The correlation between expression levels of these three forms varied on different stages of the disease (three stages on intraepithelial neoplasias and carcinomas). The function of these three hTERT forms is still not well understood

Ways to control asynchronous motor with phase rotor of mining machines

The article describes various methods of controlling asynchronous motors with a phase rotor. To solve the problems of controlling speeds and moments in a modern electric drive, two main methods of frequency control are used: scalar and vector. Advantages and disadvantages of scalar and vector control, voltage dependence are given

European experience of human resources development for micro business: relevance and implementation algorithm for the republic of Moldova

Значна частина мікропідприємств Євросоюзу являє собою самозайняті підприємства або підприємців. У країнах ЄС-28 самозайнятих підприємств, які мають 0% найманих робітників і становлять 56% від усього сектору малого та середнього бізнесу. Європейські експерти приділяють багато уваги зміцненню і розвитку даного сектора економіки. У всіх країнах ЄС організовані програми для підтримки діяльності самозайнятих підприємців, багато з яких були б корисні до впровадження в Республіці Молдова. У Молдові схожі характеристики мають мікропідприємства, які відносяться до сектору малого та середнього бізнесу і займають 85,1% від загальної кількості підприємств малого бізнесу. Відповідно, у статті було проаналізовано програми розвитку мікробізнесу у країнах Європейського Союзу, враховуючи найбільш важливі для підприємців. Новизна і практична значимість статті обумовлені рекомендаціями, які включають алгоритм впровадження європейського досвіду програм розвитку самозайнятих підприємців в секторі малого бізнесу Молдови.Many of the EU-28 SMEs are run by self-employed micro enterprises. In the EU-28 self-employed enterprises with 0% of employees consist 56% of the SME. European experts attach great importance to the strengthening and development of this sector of the economy. All EU countries have organized programs to support the activities of self-employed entrepreneurs, many of which would be useful for implementation in the Republic of Moldova. In Moldova, microenterprises have similar characteristics, which belong to the small and medium-sized business sector and occupy 85.1% of the total number of small businesses. Accordingly, the article analyzes the programs of microbusiness development in the European Union, including the most important ones, according to the entrepreneurs opinians. The novelty and practical significance of the article are due to the recommendations, including the algorithm of implementation of the European experience of development programs for self-employed entrepreneurs in the SME sector of Moldova.Значительная часть микропредприятий Евросоюза представляет собой самозанятые предприятия или предпринимателей. В странах ЕС-28 самозанятые предприятия, имеющие 0% наемных рабочих, составляют 56% от всего сектора малого и среднего бизнеса. Европейские эксперты придают большое значение укреплению и развитию данного сектора экономики. Во всех странах ЕС организованы программы для поддержки деятельности самозанятых предпринимателей, многие из которых были бы полезны к внедрению в Республике Молдова. В Молдове близкие характеристики имеют микропредприятия, которые относятся к сектору малого и среднего бизнеса и занимают 85,1% от общего числа предприятий малого бизнеса. Соответственно, в статье проанализированы программы развития микробизнеса в Европейском Союзе, включая наиболее важные, по мнению самих предпринимателей. Новизна и практическая значимость статьи обусловлены рекомендациями, включающими алгоритм внедрения европейского опыта программ развития самозанятых предпринимателей в секторе малого бизнеса Молдовы

The Red Data Book Waterbirds in the Coastal Wetlands of the Azov-Black Sea Region of Ukraine — the Results of the August Counts 2018 and 2021

The article analyses data from the August Counts of 2018 and 2021, which covered the 40 most important wetlands on the Azov-Black Sea coast of Ukraine. Of the 106 wetland bird species recorded during the censuses, 35 species are listed in the Red Data Book of Ukraine. The number of them was about 50 thousand individuals or 7.6 % of the total number of counted birds: in 2018 — 24.1 thousand individuals and in 2021 — 25.8 thousand individuals. Detailed information on the number of bird species and the list of the most important sites for each species can be found in the publication. The comparison of the current data with the previous survey period 2004‒2015 (Chernichko et al., 2018) showed that the abundance of 17 waterbird species decreased, and 7 species increased their abundance. It is assumed that these changes are caused by the aridification of the climate, leading to the drying out of the shallow parts of the region's wetlands in the second half of the summer

Dilution of the magnetic lattice in the Kitaev candidate α\alpha-RuCl3_3 by Rh3+^{3+} doping

Magnetic dilution of a well-established Kitaev candidate system is realized in the substitutional Ru$_{1-x}$Rh$_x$Cl$_3$ series ($x = 0.02-0.6$). Optimized syntheses protocols yield uniformly-doped single crystals and polycrystalline powders that are isostructural to the parental $\alpha$-RuCl$_3$ as per X-ray diffraction. The Rh content $x$ is accurately determined by the quantitative energy-dispersive X-ray spectroscopy technique with standards. We determine the magnetic phase diagram of Ru$_{1-x}$Rh$_x$Cl$_3$ for in-plane magnetic fields from magnetization and specific-heat measurements as a function of $x$ and stacking periodicity, and identify the suppression of the magnetic order at $x \approx 0.2$ towards a disordered phase, which does not show any clear signature of freezing into a spin glass. Comparing with previous studies on the substitution series Ru$_{1-x}$Ir$_x$Cl$_3$, we propose that chemical pressure would contribute to the suppression of magnetic order especially in Ru$_{1-x}$Ir$_x$Cl$_3$ and that the zigzag magnetic ground state appears to be relatively robust with respect to the dilution of the Kitaev--$\Gamma$--Heisenberg magnetic lattice. We also discovered a slight dependence of the magnetic properties on thermal cycling, which would be due to an incomplete structural transition

Модернизационные ценности как критерии поколения

Some actual sociological approaches to the problem of generations are discussed. In modern societies the generation is not a demographic category, but a resource of modernization processes.Рассматриваются современные социологические подходы к изучению проблемы поколений. Показано, что в современных обществах, переживших и переживающих процессы модернизации, поколение является не демографической категорией, а ресурсом модернизационных процессов